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The maximum time interval between doses should not exceed 12 hours.Ģ.3 Dosage Adjustment in Patients with Renal Impairmentĭosage adjustment in patients 12 years of age and older with renal impairment or undergoing hemodialysis is recommended, as follows (see dosing recommendations above for effective doses in each indication): Dosages up to 50 mg/kg/day have been well tolerated in a long-term clinical study. The recommended maintenance dose of gabapentin in patients 5 to 11 years of age is 25 mg/kg/day to 35 mg/kg/day, given in three divided doses. The recommended maintenance dose of gabapentin in patients 3 to 4 years of age is 40 mg/kg/day, given in three divided doses. The starting dose range is 10 mg/kg/day to 15 mg/kg/day, given in three divided doses, and the recommended maintenance dose reached by upward titration over a period of approximately 3 days. The maximum time between doses should not exceed 12 hours. Administer gabapentin three times a day using 300 mg or 400 mg capsules. Doses of 3600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. Dosages up to 2400 mg/day have been well tolerated in long-term clinical studies.

The recommended maintenance dose of gabapentin is 300 mg to 600 mg three times a day.

The starting dose is 300 mg three times a day. In clinical studies, efficacy was demonstrated over a range of doses from 1800 mg/day to 3600 mg/day with comparable effects across the dose range however, in these clinical studies, the additional benefit of using doses greater than 1800 mg/day was not demonstrated.Ģ.2 Dosage for Epilepsy with Partial Onset Seizures The dose can subsequently be titrated up as needed for pain relief to a dose of 1800 mg/day (600 mg three times a day).

In adults with postherpetic neuralgia, gabapentin may be initiated on Day 1 as a single 300 mg dose, on Day 2 as 600 mg/day (300 mg two times a day), and on Day 3 as 900 mg/day (300 mg three times a day).

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